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Index > Protein center > S1pr5(Gene name) > Mouse
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  • S1pr5 (Gene name),
  • Sphingosine 1-phosphate receptor 5 (Protein name ),  S1PR5_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    S1pr5(Edg8;Lpb4);
    Protein name:
    Sphingosine 1-phosphate receptor 5(S1P receptor 5;S1P5);
    Alternative:
    Lysophospholipid receptor B4;Endothelial differentiation G-protein-coupled receptor 8;Sphingosine 1-phosphate receptor Edg-8(S1P receptor Edg-8);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt-dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    400
    Sequence:
    50:
    MEPGLLRPAP | VSEVIVLHYN | YTGKLRGARY | QPGAGLRADA | AVCLAVCAFI | 
    100:
    VLENLAVLLV | LVRHPRFHAP | MFLLLGSLTL | SDLLAGAAYA | TNILLSGPLT | 
    150:
    LRLSPALWFA | REGGVFVALA | ASVLSLLAIA | LERHLTMARR | GPAPAASRAR | 
    200:
    TLAMAVAAWG | ASLLLGLLPA | LGWNCLGRLE | TCSTVLPLYA | KAYVLFCVLA | 
    250:
    FLGILAAICA | LYARIYCQVR | ANARRLRAGP | GSRRATSSSR | SRHTPRSLAL | 
    300:
    LRTLSVVLLA | FVACWGPLFL | LLLLDVACPA | RACPVLLQAD | PFLGLAMANS | 
    350:
    LLNPIIYTFT | NRDLRHALLR | LLCCGRGPCN | QDSSNSLQRS | PSAAGPSGGG | 
    400:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    KEGG:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse S1P receptor 5
    Cat.:
    E0328h
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    Packing:
    96T
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    ELISA Kit for Mouse S1P receptor 5
    Cat.:
    E0328r
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    96T
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    ELISA Kit for Mouse S1P receptor 5
    Cat.:
    E0328m
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    96T
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    ELISA Kit for Mouse S1P receptor 5
    Cat.:
    E0328p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse S1P receptor 5
    Cat.:
    U0328h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Mouse S1P receptor 5
    Cat.:
    U0328r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse S1P receptor 5
    Cat.:
    U0328p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse S1P receptor 5
    Cat.:
    U0328m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse S1P receptor 5
    Cat.:
    P0328Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse S1P receptor 5
    Cat.:
    P0328Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse S1P receptor 5
    Cat.:
    P0328Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse S1P receptor 5
    Monoclonal Antibody for Mouse S1P receptor 5
    Monoclonal Antibody for Mouse S1P receptor 5
    Monoclonal Antibody for Mouse S1P receptor 5
    Monoclonal Antibody for Mouse S1P receptor 5
    Protein for Mouse S1P receptor 5
    Protein for Mouse S1P receptor 5
    Protein for Mouse S1P receptor 5
    Protein for Mouse S1P receptor 5

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    References
    1. 1.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Liver.
    2. 2.
      "Molecular cloning of the mouse sphingosine-1-phosphate receptor gene, Lpb4."
      Yang A.H. , Zhang G. , Chun J.J.M.
      Submitted (2000-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-400
      strain: Swiss Webster / NIH.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-400
    4. 4.
      "Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors."
      Im D.-S. , Clemens J. , Macdonald T.L. , Lynch K.R.
      Biochemistry40:14053-14060(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    5. 5.
      "Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival."
      Jaillard C. , Harrison S. , Stankoff B. , Aigrot M.S. , Calver A.R. , Duddy G. , Walsh F.S. , Pangalos M.N. , Arimura N. , Kaibuchi K. , Zalc B. , Lubetzki C.
      J. Neurosci.25:1459-1469(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;FUNCTION
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